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This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

L-Carnitine is a very small molecule, soluble in water, which is found in natural and highly concentrated amounts in the muscles

Thus, a better understanding of the metabolic actions of thyroid hormones and thyromimetics in the liver is timely and clinically relevant

The following data were extracted from selected studies: year of publication, the first authors' name, study location and design, dosage of intervention, sample size, duration of study, age of subjects, type of disease, the mean and SD for glycemic control in each treatment group