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Various models are used to study PD, including -synuclein-mutant mice, the toxin MPTP, striatal injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA), and others (115)

[11] SIBO is often associated with an increased intestinal permeability and this, combined with hypochlorhydria, can exacerbate gut inflammation, leading to compromised enterocyte function, low digestive enzyme production and, because the luminal content is able to interact with immune cells, will fuel systemic inflammation

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This liposomal formulation was accompanied by a significant reduction in melanin index (MI) of melasma lesions after 2 weeks of treatment, while the alteration in MI in the normal skin was not significant (Kwon et al., 2020