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In previous studies, the expansion of polyglutamine (polyQ) bundles to 36 or more glutamine repeats will cause the HTT protein to misfold and aggregate, leading to neuronal death and symptoms of Huntingtons disease (Mangiarini et al., 1996)

Additionally, the injection products may contain aluminum which may reach toxic concentrations with prolonged administration in patients with impaired renal function or in premature neonates with immature kidneys

AOD-9604 is currently sold for research purposes only and lacks regulatory approval from any major health authority worldwide

Intramuscular (IM) route of vitamin B12 administration: The sublingual (SL) route of vitamin B12 administration has been evaluated as an alternative route to oral and IM routes, especially in the case of vitamin B12 malabsorption