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Analysis of Denmarks comprehensive diabetes database demonstrated: Analysis of all 424,152 Danish citizens with Type 2 diabetes between 2018 and 2024 106,454 patients exposed to once-weekly semaglutide versus 317,698 unexposed Hazard ratio of 2.19 (95% CI, 1.54-3.12) for NAION development More than doubling of five-year NAION risk among semaglutide users Consistent findings across multiple sensitivity analyses A parallel Danish-Norwegian cohort study examining 61,377 semaglutide users found similarly concerning results, with an adjusted hazard ratio of 2.81 (95% CI 1.67-4.75) when compared to SGLT-2 inhibitor users