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This meta-analysis revealed that L-carnitine supplementation significantly reduces levels of triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), HbA1c, HOMA-IR, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-), as well as weight, body mass index (BMI), body fat percentage (BFP), and leptin in patients with diabetes and impaired glucose tolerance

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However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical l-arginineNO-synthase pathway, in particular in hypoxic states