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Metabolic immune checkpoint ecto-5-nucleotidase (CD73) significantly inhibits the function of anti-tumor T cells and increases the activity of immunosuppressive cells by regulating the imbalance of extracellular adenosine (ADO), while multifunctional Au@Cu 2-x Se nanoparticles (ACS NPs) significantly inhibit the expression of CD73 thereby reducing ADO production, lowering ADO-driven immunosuppression and enhancing the infiltration and activity of anti-tumor T cells in tumors (240)

It binds to specific receptors on these cells, triggering a chain of intracellular signaling events

Superoxide dismutase (SOD) is a very powerful antioxidant due to its enzymatic ability to neutralize free radicals

Firas Jafri, Gyuhee Seong, and Tim Jang are equal first authors