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Activators At the transcriptional level, NFE2L2 gene is induced by several transcription factors, including the aryl hydrocarbon receptor (AhR) in response to environmental pollutants like polycyclic aromatic hydrocarbons, breast cancer susceptibility gene 1 (BRCA1) in response to xenobiotic stress, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) in response to inflammatory stimuli

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Commonly used scales, such as the NIH Stroke Scale or Glasgow Coma Scale, are calibrated for acute neurological deficits but are poorly suited to detecting the gradual, molecular-level improvements that characterize many neuroprotective strategies