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Description

Pyruvate Carboxylase Deficiency: Mechanisms, Mimics and Anaplerosis

doi: 10.5049/EBP.2013.11.2.41 25 IchiharaASuzukiFNakagawaTKaneshiroYTakemitsuTSakodaMet al

NOT recommended for treatment of type 1 diabetes or treatment of diabetic ketoacidosis Pharmacokinetics: oral administration, 65% bioavailability activity is terminated by conversion to inactive O-glucuronide metabolites (that are eliminated in the urine), with only minimal (~7%) metabolism by CYP3A4