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Compared with potent controls, ED men non-responders for oral sildenafil citrate showed significant decreases in the mean serum l-carnitine level (16.8 3.6 uM/L versus 66.3 11.9 uM/L, P = 0.001), the mean serum 25(OH)D level (21.2 7.1 ng/ml versus 54.6 7.9 ng/mL, P = 0.001) and IIEF-5 score (7.8 2.6 versus 23.9 1.3)

By the way, GS also tries to guesstimate the impact of other health innovations, and calculate a combined impact with obesity drugs: advances in computational biology, the advent of big data in healthcare, and a greater understanding of human genomics (via the Human Genome Project and a lower cost of sequencing)which have spurred innovations in areas such as AI-powered drug discovery, gene editing, improved immunotherapy, better diagnostics, and the development of more affordable biosimilar drugscould accelerate health improvements

Insulin stimulates thyroid hormone receptor alpha gene expression in cultured bovine aortic endothelial cells

(November 1984)