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A recent analysis using Mendelian randomization showed that genetically predicted homocysteine levels increased the odds of NAFLD.[ref] Related article: NAFLD genes Cardiovascular disease: To answer the question of whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease, researchers again used huge genetic data sets and Mendelian randomization to determine causality

Another one of the major yeast toxic metabolites is gliotoxin

Activation of AMPK reduces lipid accumulation by promoting fatty acid oxidation and inhibiting de novo lipogenesis 18

doi: 10.1159/000503339