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The international clinical guidelines place dietary glycemic-load management, regular movement (150 to 250 minutes of moderate exercise per week), and adequate sleep as first-line interventions (Teede et al

In response to this stress, the Kelch-like ECH-associated protein (Keap1) dissociates from the nuclear factor erythroid 2-related factor 2 (Nrf2)

Recently, a role for cytoskeleton protein filamin A (FLNA) in DRD2 and SSTRs receptors expression and signaling in PRL- and GH-secreting tumors, respectively, has been demonstrated, first revealing a link between FLNA expression and responsiveness of pituitary tumors to pharmacological therapy

Tolerability: Generally well tolerated when used appropriately