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Several studies have examined diet-induced changes in gut microbiota in mice strains fed a high fat or high sucrose diet and, in each case, a significant proportional increase in Firmicutes and decrease in Bacteroidetes was seen ( Dorea and Eubacterium rectale and decreased Bifidobacterium ( Firmicutes and reduced Bacteroidetes : Eubacterium rectale in obese individuals ( Gut barrier dysfunction and endotoxemia Intestine is one of the most crucial internal barriers and its disturbance leads to an immune response as bacterial products pass through the gut, and evidence shows that the immune systems of patients with MASLD are primed toward a pro-inflammatory state

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