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The major hurdleslack of objective diagnostic biomarkers, the BBB impeding drug delivery, significant patient heterogeneity, and the need for more sensitive clinical trial endpointscollectively form a critical barrier to progress

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A 28-day phase 1 MAD study was conducted in participants who were overweight or obese, revealing mean weight loss of 0.6%, 2.5%, 4.4%, and 5.5%, corresponding to groups administered placebo, 240 mg, 500 mg, and 740 mg ( 3.1.2.6 HRS-7535 HRS-7535 is a small molecule GLP-1 RA administered orally once a day