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Looking ahead, the authors point to what the field needs next: models that better combine physiological relevance with reproducibility and scalability, supported by accepted reference compound panels and richer multimodal readouts that can help unlock the potential of machine learning

It will be interesting to understand the functional consequences of these changes, which are relevant for possible application in the development of GLP-1R agonists for medical application in diabetes treatment and for better understanding of the function of these changes in monotreme GLP-1

In short, liraglutide, GLP-1 receptor agonist, has a direct effect on atherosclerosis lesion formation via promoting pro-resolving M2 macrophages phenotype