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Those with cardiovascular issues should also use caution because of potential effects on heart rate and blood pressure

Following study selection, data extraction was performed independently by RM and RC using a structured extraction form in Microsoft Excel, with all entries cross-checked for accuracy

[DOI] [PubMed] [Google Scholar] 92.Humphries F., Shmuel-Galia L., Ketelut-Carneiro N., et al

357 IR in adipose tissue leads to high FFAs levels, 358 visceral fat accumulation that is associated with elevated levels of plasminogen activator inhibitor 1 (PAI-1) and BP, 359 and ectopic lipid and toxic lipid metabolite accumulation (lipotoxicity) in blood vessels that alters cellular signaling and cardiac structure, thereby contributing to the increased prevalence of cardiovascular diseases