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Glutathione, a master antioxidant naturally found in the body, plays a critical role in combating free radicals and reducing oxidative stress

Over time, this process contributes to a more even, luminous, and radiant complexion

However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention

L glutathione is a tripeptide molecule composed of three amino acids: cysteine, glycine, and glutamic acid