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A2A receptor activation upregulates vascular endothelial growth factor (VEGF), promotes angiogenesis in the dermal microvasculature, stimulates fibroblast migration and proliferation, and suppresses inflammatory cytokine release

193 When muscles contract and generate force, these signals can prompt changes in gene expression and protein synthesis within fibroblasts, enhancing the ligaments resilience and repair capabilities

Doherty, C., Wilbanks, B., Khatua, S