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It directly neutralizes reactive oxygen and nitrogen species, regenerates the oxidized forms of vitamin C and vitamin E (restoring their antioxidant activity), and serves as a cofactor for glutathione peroxidase enzymes that reduce hydrogen peroxide and lipid peroxides

In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)

PBK promotes autophagy by activating the ERK/mTOR signaling pathway, thereby enhancing resistance to platinum drugs (122)

GUO: These compounded drugs, they don't have to go through the same FDA approval process as new medications or their generic counterparts