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The potential risks include digestive discomfort, gas, and bloating. They can also reduce the absorption of certain medications like lithium, certain antidepressants, digoxin, diabetes medications, bile acid sequestrants, and carbamazepine

The LEO intervention group exhibited a marked elevation in the relative abundance of Alistipes (genus-level) and the uncultured candidate species bacterium_0_1xD8_71, whereas a concurrent reduction was detected in Phocaeicola sartorii (species-level) and Phocaeicola (genus-level) populations

GHK-Cu is naturally occurring in the human body and is generally very well tolerated

Participants with normal hepatic function were eligible for inclusion if they were judged to be of general good health by the investigator, based on a medical examination (including physical examination, medical history, vital signs and ECG) and had liver enzyme levels within prespecified limits (alanine aminotransferase upper limit of normal [ULN] + 10%, aspartate aminotransferase ULN + 20% and total bilirubin ULN + 20%)