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The VEGFR2 pathway and nitric oxide synthesis via the Akt-eNOS axis promote angiogenesis, restoring blood supply to damaged nerve tissue

533 Topical agents such as the capsaicin 8% patch provide localized pain relief by desensitizing nociceptive fibers, while the lidocaine patch 5% is useful for focal neuropathic pain with a favorable safety profile

It binds the human GLP-1 receptor, lowers blood sugar, and resists degradation by dipeptidyl-peptidase 4 (DPP-4) because it has glycine-not alanine-at position 2