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M., Du, Y., Lou, J., Gurbuz, S., Milicevic, Z., Coskun, T., Hartman, M

ROS are implicated in these metabolic derangements, playing a central role in the pathogenesis of NAFLD

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However, most in vitro studies have identified MSU crystals as inflammasome activators needed to use lipopolysaccharide (LPS) or phorbol-12-myristate-13-acetate (PMA) to trigger the activation of the inflammasome in cells ( Further exploration revealed that during the course of inflammation, FA-related metabolic disorders promote inflammation by affecting the metabolism and microenvironment of macrophages and neutrophils ( 2 Comprehensive overview of fatty acids FAs are organic acids that are defined mainly by the length and saturation of their aliphatic side chain