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A one-way ANOVA with Dunnetts multiple comparisons test was used for (A) and (B)

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Inhibiting glutamine pathway, including downregulating glutamine transporter ASCT2 [84] or inhibit glutaminase by CB-839 [85] can deplete intracellular GSH, but such effect of CB-839 was only observed in cancer cell lines expressing xCT supplied with high cystine in the culture [86]