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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB (Deng et al., 2024)

The relative lack of side effects is particularly important for those with recurring or chronic pain, as it lowers the risks associated with multiple injections

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Wegovy: In trials of the 25 mg pill, participants lost an average of 13.6% of body weight over 71 weeks, compared to just over 2% in the placebo group