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IHT is often investigated in 20-day programs of 58 daily cycles of 510 min moderate intense hypoxia (9.5%10% O 2 ) and 4 min exposures to normoxia (21% O 2) , with each daily session totaling 4598 min (Jung and Mallet, 2018)

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Standard R-lipoic acid is notoriously unstable, readily polymerizing into inactive forms when exposed to heat, light, or moisture

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Allow the vial to reach room temperature before introducing the solvent slowly against the inside wall and gently swirl until fully dissolved

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