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The process can be initiated by elevated glucose or insulin, and liver X receptor A, thereby promoting hepatic lipid accumulation and regulating to lipid-producing genes such as Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1, and Fatty Acid Synthase (FASN) (Geidl-Flueck and Gerber 2023

Grasset E, Puel A, Charpentier J, et al

3 Macrophage polarization and immunometabolism The functional states of macrophages are not only regulated by microenvironmental inflammatory signals, but are also closely associated with dynamic reprogramming of intracellular metabolic networks, thereby exhibiting a high degree of plasticity

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