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In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

All subtypes affect women and men with an equal frequency and have a similar prognosis with cure rates of between 95 and 100% [25]

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Both of my girls had horrible stomach issues as teens and numerous food allergies/intolerances, inflammation and a leaky gut, which led to anxiety, depression, ADD, OCD, etc