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Key limitations include: No completed randomized controlled trials in humans Most data derived from animal models, limiting direct translatability Publication bias may favor positive results Long-term safety data in humans is not available Optimal dosing for human applications has not been established Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers , published in Journal of Alternative and Complementary Medicine (Allen J and Bradley RD, 2011
Notes: Researchers have not tested doses higher than 21.4mcg/kg/daily
These markers are inexpensive to track through routine bloodwork and provide an objective measure of hepatic response to the protocol
"Pernicious Anemia", StatPearls , Treasure Island (FL): StatPearls Publishing, PMID 31082033, retrieved July 15, 2025 "Vitamin B12 or folate deficiency anaemia Diagnosis"
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