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El primer GLP-1, la exenatida (Byetta), fue aprobado por primera vez por la Administracin de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en ingls) en 2009 como un inyectable dos veces al da, que debe administrarse dentro de una hora de las comidas de la maana y la noche

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How They Differ The differences are entirely in dosage, FDA approval, and marketing : Ozempic (Diabetes Medication) FDA-Approved Use: Treatment of Type 2 Diabetes Mellitus Reducing cardiovascular risk in diabetic patients Dosing Schedule: Starting dose: 0.25 mg weekly (first 4 weeks) Maintenance dose: 0.5 mg or 1.0 mg weekly Maximum dose: 2.0 mg weekly Intended Primary Effect: Blood sugar control A1C reduction Weight Loss Status: Acknowledged as a side effect Not the primary indication Insurance may not cover for weight loss alone Off-Label Use Reality: Many doctors prescribed Ozempic specifically for weight loss before Wegovy became available