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Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

Investigators have examined the molecule in animal-model and in-vitro work covering tissue repair, gastric mucosal protection, angiogenic signalling, and anti-inflammatory cascades

Yet, whether potential protection conferred by isothiocyanates via the Nrf2-dependent pathway is diminished in individuals carrying GST null variants is currently unknown