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Therefore, topical delivery primarily aims to replenish a naturally declining system rather than introduce a foreign bioactive

doi: 10.3389/fnmol.2021.696476 Received 16 April 2021 Accepted 27 May 2021 Published 17 June 2021 Volume 14 - 2021 Edited by Touqeer Ahmed, National University of Sciences & Technology, Pakistan Reviewed by Francesco Di Lorenzo, Santa Lucia Foundation (IRCCS), Italy

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We report on the clinical and molecular characteristics of 20 additional patients with clEDS to expand knowledge and to enable improved management of this rare genetic disorder