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Treatment intensification should generally proceed with appropriate eye monitoring rather than be delayed, as the long-term benefits of improved glycemic control substantially outweigh the risk of early worsening in most patients

This makes it harder to figure out the right dose, and its effects can last much longer

The diagnosis of HAE was made in the presence of clinical symptoms and laboratory criteria (low levels of C1-inhibitor antigen and/or function, low level of C4 complement), accompanied by a positive family history