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The key anti-inflammatory effects included: Modulation of macrophage activation states Decreased reactive nitrogen species production Reduced efferocytotic activity in treated cells Lower expression of pro-inflammatory mediators Research on corneal injuries found TB-500 suppressed multiple inflammatory mediators while maintaining bacterial clearance when combined with antibiotics

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Peripheral blood mononuclear cells (PBMC) isolated from COPD patients showed defective signaling of the GLP-1 receptor compared to subjects without COPD