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FIGURE 1 2.1 Iron metabolism imbalance Iron, an essential trace element, primarily participates in metabolic processes in the forms of Fe 2+ and Fe 3+ ( 2+ absorbed in the intestines or released from erythrocyte degradation is oxidized to Fe 3+ by ceruloplasmin (CP) in the circulation

Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007

doi: Kosiborod MN, Bhatta M, Davies M, et al

The cursory pharmacokinetic characterization of dihexa included in this study indicated that it was stable in serum, had a long circulating half-life, and penetrated the BBB