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Teng Xu and colleagues identified that, in head and neck squamous cell carcinoma (HNSCC), the DLG motif within tumor necrosis factor--induced protein 2 (TNFAIP2) competes with the Kelch domain of Keap1, thereby inhibiting the ubiquitin-proteasome-mediated degradation of NRF2

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Clinicians should be aware of potential interactions with narrow therapeutic index drugs that depend on rapid absorption (e.g., oral contraceptives, levothyroxine, warfarin) and may need to adjust timing or monitoring accordingly