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A meta-analysis of randomized controlled trials found that daily vitamin E supplementation equivalent to 25 to 536 mg/day of RRR --tocopherol for several years resulted in a significant, 10% reduction in the risk of ischemic stroke (five trials, 91,393 participants) and a nonsignificant trend towards an increased risk of hemorrhagic stroke (five trials, 100,748 participants) (120)

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Although the overall number of CD4+ T cells can initially regenerate, different subsets of CD4+ T cells (i.e., Th1, Th2, Th17, Treg, etc.) are disproportionately depleted and never return to homeostatic levels [12]