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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

Presentation after next 2 weeks ( c, b ): in control rats, drinking water was continuously given (12 ml/day/rat) (defecation through fistula, c ) and in BPC 157 rats, BPC 157 (10 g/kg/day) was given in drinking water (0.16 g/ml/day/rat) (fistula closed, b )