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The schedule mirrors the clinical-trial protocols that drove substantial weight loss around 20% of body weight over 72 weeks on the 15 mg dose [2] while holding gastrointestinal effects down through gradual escalation [1] [4]

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To be included in the RWD set, patients needed to have chronic kidney disease as defined by ICD-10 codes N18, N19, or I12, or eGFR 60%) incorporated at least one medication code pertaining to the cardiovascular system (ATC codes beginning with 'C') and at least one code related to diabetes medications (ATC codes beginning with 'A*')