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Approximately 25% of pediatric cancer diagnoses are associated with acute lymphoblastic leukemia (ALL), indicating that ALL is the most prevalent form of cancer in the pediatric population ( Chemotherapy, whether administered as monotherapy or in conjunction with alternative therapeutic modalities, continues to be the primary treatment for ALL (Sheykhhasan et al., 2022

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In vitro , the expression of HGF in hepatic stellate cells underwent a dramatic decrease under hypoxia, and the same as c-Met in hepatocytes (Lee et al., 2019)

(26-28) Additionally, patient populations differed, with Werkman et al