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Investigations have revealed a significant impact of a modest elevation in ACC phosphorylation by AMPK and the phosphorylation of hippocampal calcium-binding protein-like 1 (HPCAL1) at Thr149 mediated by protein kinase C theta (PRKCQ) can activate the autophagic degradation of cadherin 2 (CDH2) and partially protect cells from erastin-induced cell death[103]

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