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Certain microbes have been identified to express TMA lyases, including the commonly reported choline TMA lyase (cutC/D), carnitine Rieske oxygenase/reductase (cntA/B), betaine reductase, TMAO reductase (TMAOase), ergothionase, and -butyrobetaine utilizing enzyme (Gbu) [1820, 22, 23]

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The researchers specifically showed that IMP2, which is involved in controlling oxygen consumption rate (OCR), mitochondrial mass, and the expression of various stemness markers, including CD133, SOX2, OCT4, and NANOG, is more highly expressed in CD133 + glioblastoma cells