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56 FangR.LinJ.YaoS.WangY.WangJ.ZhouC.et al

Initial evaluation of whitening properties in vitro should be conducted on purified TYR and/or other melanogenic proteins, followed by the use of melanocyte cultures to examine potential cytotoxic and melanin synthetic effects

A meta-analysis of randomized controlled trials found that daily vitamin E supplementation equivalent to 25 to 536 mg/day of RRR --tocopherol for several years resulted in a significant, 10% reduction in the risk of ischemic stroke (five trials, 91,393 participants) and a nonsignificant trend towards an increased risk of hemorrhagic stroke (five trials, 100,748 participants) (120)