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Store in the refrigerator at 28C (3646F) Protect from light and heat Do not freeze Use within 30 days of opening Reconstitution is not required

Drinking plenty of fluids may reduce your chance of dehydration

Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cells antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment ( Chemical inhibition of key points of glutamine metabolism, such as GLS and MYC, or genetic knockdown of these genes and glutamine transporters, suppresses glutamine decomposition, thereby inhibiting crucial CSC-driving pathways (WNT/-catenin, the oxidative stress response, and the DNA damage response), resulting in CSC depletion both in vitro and in vivo and enhancing tumor radiosensitivity

In addition to normalizing the intracellular redox state, antioxidants directly influence the regulation of MAPK and transcription factors and can reduce the production of MMPs, restoring their levels to normal (79)