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Eligible participants take part under the supervision of a professional clinical study team, with regular check-ins and health assessments

A January 2025 randomized trial in JAMA Psychiatry found those using low-dose semaglutide to be at a lower risk of hospitalizations related to alcohol use than those who were not using it

Additionally, semaglutide should not be used by: Pregnant people People of any sex planning to conceive in the near future Anyone with a personal or family history of certain thyroid cancers, including medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia syndrome type 2 (MEN 2) Phentermine should not be used by people who are pregnant or nursing, who have recently started taking monoamine oxidase inhibitors, or who have: A history of heart problems Hyperthyroidism Glaucoma Agitation A history of substance use disorder Who should not combine semaglutide and phentermine

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