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These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods

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Sertoil cells also be needed to break down glucose to produce lactic acid to maintain spermatogenesis, and hormones such as FSH, testosterone, and insulin fundamentally control this process (Galardo et al

These conflicting results may reflect context-dependent actions of LCN2 in bone and/or differences in the underlying genetic models