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First identified in human plasma in the 1970s, this small tripeptide glycyl-L-histidyl-L-lysine, bound to a copper ion has become one of the most extensively referenced compounds in dermal and wound-healing research literature, largely because its copper-binding structure gives it a distinct mechanism from most other peptide sciences on the market

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B vitamin status Vitamin B12 deficiency is a well-established cause of peripheral neuropathy, and several GLP-1 formulations now include B12 specifically because of concerns about nutritional status during weight loss

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