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The major ferroptosis-related pathways influenced by polysaccharides are the SLC7A11/GSH/GPX4 pathway, Keap1/Nrf2/HO-1 pathway, NCOA4-mediated ferritinophagy pathway, ACSL4-mediated lipid peroxidation pathway, and their upstream signal such as PI3K/Akt, Wnt/-catenin, p53, and the AMPK/BECN1 autophagy pathway

Among those with preexisting substance use disorders, GLP-1 takers had lower risks of hospitalization, overdose and suicidal ideation

Weight reduction alone does not reverse central sensitization, the core mechanism of fibromyalgia, making GLP-1 therapy insufficient as a primary pain management strategy

And a third pathway, one that has become central to autoimmune research, generates regulatory T cells, also called Tregs