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[12] These are hypothesis-generating observations from uncontrolled or retrospective designssusceptible to confounding, selection, and expectation effectsand reviews of GLP-1 agents in eating disorders consistently caution that the evidence base remains preliminary, with a notable absence of large, adequately powered randomized trials in BED

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The most common mechanistic models are: animal growth models (AGM), which detail energy and mass balance to predict individual growth based on supply and metabolic costs