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The activation of the costimulatory receptor CD28 induces PDE4, resulting in the hydrolysis of cAMP, the induction of NF-B, activator protein-1 (AP-1) and NFAT, as well as the activation and proliferation of T cells

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129 Royal Jelly Royal jelly is a nutrient-dense substance produced by nurse bees and fed to queen bees throughout their lives and to worker bees in the early larval stage