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Clinical variables Symptoms such as paresthesia, asthenia, loss or reduction of appetite, sadness or change in state of mind (anamnesis), Hunters glositis, positional and vibrational sensitivity (all via physical examination), and cognitive decline (Lobo test)

Risk factors include underlying renal insufficiency, intravascular volume depletion (sometimes seen in people on strong diuretics, as well as those with poor oral fluid intake, gastroenteritis, or chronic diarrhea), diabetes, heart failure, being 60 years of age or older, exposure to multiple nephrotoxins, etc

The timing and duration of the drug holiday will be unique for each child and family

However, like any medication or compound, it is important to be aware of the potential side effects that may arise from its use