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Symptoms can begin as early as the first week, particularly within 2448 hours after the first dose or after a dose increase

As high as 58.8% of the participants had established CVD without chronic kidney disease (CKD) with an additional 13.4% having both CVD and CKD

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ORCID: Affiliation: 4 Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada These authors contributed equally to this work